More than 2,000 years ago, Hippocrates — the father of modern medicine — suggested that all disease begins in the gut.
While some of his wisdom has stood the test of time, you may wonder whether he was right in this regard.
This article tells you all you need to know about the connection between your gut and disease risk.
Though Hippocrates was incorrect in suggesting that all disease begins in your gut, evidence shows that many chronic metabolic diseases do.
Your gut bacteria and the integrity of your gut lining strongly affect your health.
According to numerous studies, undesirable bacterial products called endotoxins can sometimes leak through your gut lining and enter your bloodstream.
Your immune system then recognizes these foreign molecules and attacks them — resulting in chronic inflammation.
Some hypothesize that this diet-induced inflammation may trigger insulin and leptin resistance — driving factors for type 2 diabetes and obesity, respectively. It’s also believed to cause fatty liver disease.
At the very least, inflammation has been strongly linked to many of the world’s most serious conditions.
Nonetheless, keep in mind that this area of research is rapidly developing, and current theories may be overhauled in the future.
SUMMARY
Though not all disease begins in the gut, many chronic metabolic conditions are hypothesized to be caused or influenced by chronic gut inflammation.
Effects of Chronic Inflammation
Inflammation is your immune system’s response to foreign invaders, toxins, or cell injury.
Its purpose is to help your body attack these unwanted invaders and begin repair of damaged structures.
Acute (short-term) inflammation, such as after a bug bite or injury, is generally considered a good thing. Without it, pathogens like bacteria and viruses could easily take over your body, causing sickness or even death.
However, another type of inflammation — called chronic, low-grade, or systemic inflammation — may be harmful, as it’s long term, may affect your entire body, and inappropriately attacks your body’s cells.
For example, your blood vessels — such as your coronary arteries — may be inflamed, as well as structures in your brain.
Chronic, systemic inflammation is now believed to be one of the leading drivers of some of the world’s most serious conditions.
These include obesity, heart disease, type 2 diabetes, metabolic syndrome, Alzheimer’s disease, depression, and numerous others.
Still, the exact causes of chronic inflammation are currently unknown.
Endotoxins and Leaky Gut
Your gut houses trillions of bacteria — collectively known as your gut flora.
While some of these bacteria are beneficial, others are not. As a result, the number and composition of your gut bacteria can greatly affect both your physical and mental health.
The cell walls of some of your gut bacteria — called gram-negative bacteria — contain lipopolysaccharides (LPS), large molecules also known as endotoxins.
These substances can cause an immune reaction in animals. During an acute bacterial infection, they can lead to fever, depression, muscle pains, and even septic shock.
In addition, these substances can sometimes leak from the gut into the bloodstream — either constantly or right after meals.
Endotoxins may either be carried into your blood circulation along with dietary fat, or they may leak past the tight junctions that are supposed to prevent unwanted substances from getting across your gut lining.
When this happens, they activate immune cells. Though their amounts are too small to cause symptoms of an infection like fever, they’re high enough to stimulate chronic inflammation, causing issues over time.
Therefore, increased gut permeability — or leaky gut — may be the key mechanism behind diet-induced chronic inflammation.
When endotoxin levels in your blood increase to levels that are 2–3 times higher than normal, this condition is known as metabolic endotoxemia.